Selena famously received a kidney from her friend Francia Raisa last year, after being diagnosed with Lupus.
'The Weeknd Almost gave Selena Gomez his Kidney and I can't even get a text back,' many fans tweeted.
The Weeknd almost gave Selena Gomez his kidney only for her to get back together with her ex,' many more lamented.
The majority of tweets however thanked Gomez for her public service.
'Shout out to Selena Gomez for breaking The Weeknd’s heart, cause i needed this album,' one summarized .
Other lyrics form his new EP My Dear Melancholy are believed to relate to his brief but intense romance with his fellow singer, which took place between two of her relationships with Justin Bieber.
'Guess I was just another pit stop / 'Til you made up your mind / You just wasted my time,' he also laments in Call Out My Name.
He also talks about how the duo found each other during trying times with the lyrics: 'We found each other / I helped you out of a broken place / You gave me comfort / But falling for you was my mistake.'
The Weeknd and Selena began dating at the start of 2017, during which time the starlet largely kept out of the spotlight while dealing with her health and other personal matters.
Soon after Tesfaye and Gomez's split in October 2017, she was seen spending time with on-off ex Justin Bieber.
The I Feel It Coming singer enjoyed a stroll out in LA Thursday, only hours after releasing his highly anticipated EP the night prior.
Immediately after the record's release, fans of the Toronto, Canada native were sent into a frenzy as they speculated about which songs were about the musician's famous ex girlfriends.
The Starboy singer — birth name Abel Makkonen Tesfaye — was also previously linked to as well as model Bella Hadid, 21.
While out, the Grammy winner was dressed down in a baggy hoodie, grey sweatpants and a backwards cap while appearing at ease after dropping his follow-up to 2016's hit Starboy
Another tune, titled Wasted Times, had fans thinking he was singing about missing ex Bella Hadid.
It was hard to read the provocative line: 'You were equestrian, so ride it like a champion' as anything other than a reference to the IMG beauty, whose passion for horseback riding is no secret.
'Wasted times I spent with someone else,' he continued, possibly referring to his ill-fated romance with Gomez.
Though it's been rumored The Weeknd and Bella are hanging out once more, he hinted that the pair weren't exactly on speaking terms, singing: 'But you've been with me from the beginnin' (ooh, yeah, yeah) / And I know right now that we're not talkin' (not talkin'.)'
The Weekend and Bella began dating at the start of 2015 and were first spotted together during Coachella of that same year.
But the duo split up in November of 2016, citing 'scheduling conflicts' as the reason for their break-up
It appears that a reunion could be on the horizon, though. Since The Weeknd called things quits with Gomez last fall, he and Bella have been rumored to be spending time together once again.
The musical artist was even seen leaving Bella's NYC apartment after late-night rendezvous last November.